Anti-WDR1 Antibody Picoband® (monoklonale, 5C11C8) fluoro488 Vervoeging

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene. It is mapped to 4p16.1. This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.

Cofilin-2; Cofilin, muscle isoform; CFL2

WDR1

9948

O75083

Human, Mouse

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human WDR1, different from the related mouse and rat sequences by one amino acid.

Clone: 5C11C8

Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.

Flow Cytometry

Cell Adhesion Proteins, Epigenetics and Nuclear Signaling, Integrins, Mediator Complex, Neuroscience, Receptors, Transcription

Immunogen affinity purified.

Liquid

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.

1. Entrez Gene: WDR1 WD repeat domain 1. 2. Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999) . A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. Genomics 56 (1) : 59–69. 3. Fujibuchi T, Abe Y, Takeuchi T, et al. (2005) . AIP1/WDR1 supports mitotic cell rounding. Biochem. Biophys. Res. Commun. 327 (1) : 268–75.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Cofilin 2

Cytoskeleton. Nucleus matrix.

Mouse IgG2b

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.