Anti-WDR24 Antibody Picoband® 31.0550 Vervoeging

WD repeat-containing protein 24 is a protein that in humans is encoded by the WDR24 gene. WDR24 is a component ofthe GATOR2 complex which hasfive known subunits (WDR24, WDR59, Mios, Sec13, and Seh1L) . GATOR2 complex positively regulates mTORC1 signaling by acting upstream of orin parallel to GATOR1, which is a GTPase-activating protein (GAP) for RagA or RagB and an inhibitor ofthe amino-acid-sensing pathway.

Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a; TIMM17A; MIMT17; TIM17; TIM17A; TIMM17

WDR24

84219

Q96S15

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human WDR24 recombinant protein (Position: H309-H762) .

Flow Cytometry

Cancer, Metabolism, Mitochondrial Metabolism, Organelle Proteins, Pathways and Processes, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

1. Robert, A. , Saxton, Kevin, E. , Knockenhauer, Rachel, L. , & Wolfson, et al. (2016) . Structural basis for leucine sensing by the sestrin2-mtorc1 pathway. Science (New York, N.Y.) . 2. Wolfson, R. L. , Chantranupong, L. , Saxton, R. A. , Kuang, S. , Scaria, S. M. , & Cantor, J. R. , et al. (2016) . [Research Article] Sestrin2 is a leucine sensor for the mTORC1 pathway. 3. Wang, D., Xu, C., Yang, W., Chen, J., Ou, Y., Guan, Y., ... & Liu, Y. (2022) . E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Molecular Cell, 82 (4), 770-784.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Translocase of inner mitochondrial membrane 17A

Mitochondrion inner membrane, Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.