Anti-WDR36 Antibody Picoband® 31.0550 Vervoeging

WD repeat-containing protein 36 is a protein that in humans is encoded by the WDR36 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG) .

Protein phosphatase 1 regulatory subunit 14A;17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17, PPP1INL

WDR36

134430

Q8NI36

Human

No cross-reactivity with other proteins

E.coli-derived human WDR36 recombinant protein (Position: R74-D865) .

Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. .

Flow Cytometry

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Immunogen affinity purified.

Liquid

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

1. Bernstein, K. A., Gallagher, J. E. G., Mitchell, B. M., Granneman, S., Baserga, S. J. The small-subunit processome is a ribosome assembly intermediate. Eukaryotic Cell 3: 1619-1626, 2004. 2. Fingert, J. H., Alward, W. L. M., Kwon, Y. H., Shankar, S. P., Andorf, J. L., Mackey, D. A., Sheffield, V. C., Stone, E. M. No association between variations in the WDR36 gene and primary open-angle glaucoma. Arch. Ophthal. 125: 434-436, 2007. 3. Footz, T. K., Johnson, J. L., Dubois, S., Boivin, N., Raymond, V., Walter, M. A. Glaucoma-associated WDR36 variants encode functional defects in a yeast model system. Hum. Molec. Genet. 18: 1276-1287, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

16693 MW

6

Protein phosphatase 1 regulatory subunit 14A

Cytoplasm .

Protein phosphatase 1 regulatory subunit 14A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.