Anti-WDR46 Antibody Picoband® fluoro488 Vervoeging

WD repeat-containing protein 46 is a protein that in humans is encoded by the WDR46 gene. Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) . Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus.

Mediator of RNA polymerase II transcription subunit 9; Mediator complex subunit 9; MED9; MED25

WDR46

9277

O15213

Human

No cross-reactivity with other proteins.

E.coli-derived human WDR46 recombinant protein (Position: E166-K495) .

Expressed in fetal brain, fetal lung, fetal liver, heart, brain, placenta, lung, liver, muscle, kidney and pancreas.

Flow Cytometry

Epigenetics and Nuclear Signaling, Mediator Complex, Pol II Transcription, Polymerase Associated Factors, RNA Polymerase, Transcription

Immunogen affinity purified.

Liquid

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Herberg, J. A., Beck, S., Trowsdale, J. TAPASIN, DAXX, RGL2, HKE2, and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. J. Molec. Biol. 277: 839-857, 1998. 2. Rosenberg, S. A., Tong-On, P., Li, Y., Riley, J. P., El-Gamil, M., Parkhurst, M. R., Robbins, P. F. Identification of BING-4 cancer antigen translated from an alternative open reading frame of a gene in the extended MHC class II region using lymphocytes from a patient with a durable complete regression following immunotherapy. J. Immun. 168: 2402-2407, 2002. 3. Wada, K., Sato, M., Araki, N., Kumeta, M., Hirai, Y., Takeyasu, K., Furukawa, K., Horigome, T. Dynamics of WD-repeat containing proteins in SSU processome components. Biochem. Cell Biol. 92: 191-199, 2014.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Mediator complex subunit 9

Nucleus .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.