Anti-WDR7 Antibody Picoband® 31.0550 Vervoeging

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds ly with Rab3A GDP/GTP exchange protein and inly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described.

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

WDR7

23335

Q9Y4E6

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human WDR7 recombinant protein (Position: Q258-Q1292) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

1. Course, M. M., Gudsnuk, K., Smukowski, S. N., Winston, K., Desai, N., Ross, J. P., Sulovari, A., Bourassa, C. V., Spiegelman, D., Couthouis, J., Yu, C.-E., Tsuang, D. W., Jayadev, S., Kay, M. A., Gitler, A. D., Dupre, N., Eichler, E. E., Dion, P. A., Rouleau, G. A., Valdmanis, P. N. Evolution of a human-specific tandem repeat associated with ALS. Am. J. Hum. Genet. 107: 445-460, 2020. 2. Kawabe, H., Sakisaka, T., Yasumi, M., Shingai, T., Izumi, G., Nagano, F., Deguchi-Tawarada, M., Takeuchi, M., Nakanishi, H., Takai, Y. A novel rabconnectin-3-binding protein that ly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca (2+) -dependent exocytosis of neurotransmitter. Genes Cells 8: 537-546, 2003. 3. Nagase, T., Ishikawa, K., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 31-39, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

DAP3 binding cell death enhancer 1

Mitochondrion.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.