Anti-Wnt5a Konijn Monoklonale Antilichaam

Boster Bio Anti-Wnt5a Rabbit Monoclonal Antibody catalog # M00549. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

Protein Wnt-5a; WNT5A

WNT5A

7474

P41221

Human

A synthesized peptide derived from human Wnt5a

Clone: ABEE-23

Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level) . .

WB, ICC, IF, Flow Cytometry

Cancer, Neural Signal Transduction, Neurology Process, Neuroscience, Oncoproteins/Suppressors, Secreted, Signaling Pathways, Stem Cells, Tumor Suppressors

Affinity-chromatography

0.5mg/ml

Liquid

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00549

42339 MW

42 kDa, 48 kDa

Protein Wnt-5a

Secreted, extracellular space, extracellular matrix.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.