Anti-WNT8B Antibody Picoband® 0,00647 Vervoeging

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.

Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; GPD1L; KIAA0089

WNT8B

7479

Q93098

Human

No cross-reactivity with other proteins.

E.coli-derived human WNT8B recombinant protein (Position: A206-R340) .

Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.

Flow Cytometry

Cancer, Cell Biology, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction

Immunogen affinity purified.

Liquid

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD (H) balance induced by DPD1L.

1. Houart, C., Caneparo, L., Heisenberg, C.-P., Barth, K. A., Take-Uchi, M., Wilson, S. W. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron 35: 255-265, 2002. 2. Lako, M., Lindsay, S., Bullen, P., Wilson, D. I., Robson, S. C., Strachan, T. A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. Hum. Molec. Genet. 7: 813-822, 1998. 3. Lako, M., Strachan, T., Curtis, A. R. J., Lindsay, S. Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24. Genomics 35: 386-388, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

Glycerol-3-phosphate dehydrogenase 1 like

Cytoplasm.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.