Anti-YTHDC2 Antibody Picoband® fluoro550 Vervoeging

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene. This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line.

One cut domain family member 2; Hepatocyte nuclear factor 6-beta; HNF-6-beta; One cut homeobox 2; Transcription factor ONECUT-2; OC-2; ONECUT2; HNF6B

YTHDC2

64848

Q9H6S0

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human YTHDC2 recombinant protein (Position: K105-K1231) .

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Flow Cytometry

Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Immunogen affinity purified.

Liquid

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

1. Fanale, D., Iovanna, J. L., Calvo, E. L., Berthezene, P., Belleau, P., Dagorn, J. C., Bronte, G., Cicero, G., Bazan, V., Rolfo, C., Santini, D., Russo, A. Germline copy number variation in the YTHDC2 gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcinoma susceptibility? Expert Opin. Ther. Targets 18: 841-850, 2014. 2. Jain, D., Puno, M. R., Meydan, C., Lailler, N., Mason, C. E., Lima, C. D., Anderson, K. V., Keeney, S. ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. eLife 7: e30919, 2018. Note: Electronic Article. 3. Morohashi, K., Sahara, H., Watashi, K., Iwabata, K., Sunoki, T., Kuramochi, K., Takakusagi, K., Miyashita, H., Sato, N., Tanabe, A., Shimotohno, K., Kobayashi, S., Sakaguchi, K., Sugawara, F. Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. PLoS One 6: e18285, 2011. Note: Electronic Article.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

One cut homeobox 2

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.