Anti-YY1 Antilichaam Picoband® (monoklonale, 3F3E7) fluoro488 Vervoeging

YY1 (Yin Yang 1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene. YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

Dihydrofolate reductase; DHFR

YY1

7528

P25490

Human, Mouse, Rat

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence in the middle region of human YY1, identical to the related mouse sequence.

Clone: 3F3E7

Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Cancer, Cell Biology, Metabolic Signaling Pathways, Metabolism, Nucleotide Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.

1. Shi Y, Seto E, Chang LS, Shenk T (Oct 1991) . Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67 (2) : 377–88. 2. Thiaville MM, Kim J (2011) . Oncogenic potential of yin yang 1 mediated through control of imprinted genes. Critical Reviews in Oncogenesis 16 (3-4) : 199–209. 3. Zhu W, Lossie AC, Camper SA, Gumucio DL (Apr 1994) . Chromosomal localization of the transcription factor YY1 in the mouse and human. Mammalian Genome 5 (4) : 234–6.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Dihydrofolate reductase

Mitochondrion. Cytoplasm

Zeta chain of T cell receptor associated protein kinase 70

Mouse IgG1

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.