Anti-ZBED1 Antilichaam

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.

Boster Bio Anti-ZBED1 Antibody (Catalog # A11133) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

ALTE, DREF, TRAMP, hDREF, ALTE, KIAA0785, Zinc finger BED domain-containing protein 1, Putative Ac-like transposable element

ZBED1

O96006

Human, Mouse

This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.

ZBED1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human ZBED1. The immunogen is located within amino acids 180 - 230 of ZBED1.

Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.

ELISA, WB

Homeostasis

ZBED1 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.

ZBED1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A11133

78156 MW

Zinc finger, BED-type containing 1

Nucleus

Zinc finger, BED-type containing 1

IgG

ZBED1 Antibody is supplied in PBS containing 0.02% sodium azide.