Anti-ZCCHC8 Antilichaam

The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. ZCCHC8 acts as a scaffold, mediating the interaction between RBM7 and MTR4. NEXT is involved in exosome-mediated surveillance and decay of noncoding RNAs, such as enhancer RNAs (eRNAs) and aberrant 3′-extended transcripts from small nuclear RNA (snRNA), telomerase RNA, and replication-dependent histone genes. NEXT is an important node in regulating nuclear exosome activities and takes part in several biological processes, including DNA damage response, stress response, and viral ribogenesis . ZCCHC8 also has a robust interaction with YTHDC1 (PMID: 28984244) .

Boster Bio Anti-ZCCHC8 Antibody catalog # A10566-1. Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse.

ZCCHC8

ZCCHC8

Q6NZY4

Human, Mouse

E.coli-derived human ZCCHC8 recombinant protein (Position: V357-A705) .

WB, IHC, ICC, IF, ELISA

Immunogen affinity purified.

500 μg/mL

Liquid

12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A10566-1

Zinc finger CCHC-type containing 8

Zinc finger CCHC domain-containing protein 8

500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.