Antilichaam translineren

Translin Antibody: Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.

7247

Q15631

NP_004613

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

Translin Antibody is affinity chromatography purified via peptide column.

Cat. No. 1462 - Rat Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)

Translin Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Translin antibody can be stored at 4 ˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of Translin are known to exist; this antibody will detect both.

TSN

Cat. No. 10-101 - Human Lung Tissue Slide

Translin

Homo sapiens

Aoki K, Susuki K, Sugano T, et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Nat. Genet. 1995; 10:167-74.

Li Z, Wu Y, and Baraban JM. The Translin/Trax RNA binding complex: clues to function in the nervous system. Biochim. Biophys. Acta 2008; 1779:479-85

Translin Antibody: C3PO, RCHF1, TBRBP, TRSLN, BCLF-1, REHF-1, Translin, Component 3 of promoter of RISC, C3PO

ELISA, WB, IHC-P, IF

4759270

Liquid