Antilipoom-preferred partner LPP Antibody Picoband® 310647 Vervoeging

LPP (Lim Domain-Containing Preferred Translocation Partner in Lipoma) is a protein that in humans is encoded by the LPP gene. Petit et al. (1996) commented that the LPP-encoded protein should be classified as a novel member of the group 3 proteins of the LIM protein gene family. By partial cDNA cloning, Petit et al. (1996) established features of the genetic organization of LPP. The gene was found to span a genomic region of over 400 kb. By FISH and Southern blot analyses, Daheron et al. (2001) identified a rearrangement in the mixed lineage leukemia gene due to a novel t (3;11) (q28; q23) translocation in a patient who developed acute myeloid leukemia of the M5 type 3 years after treatment for a follicular lymphoma.

Lipoma-preferred partner; LIM domain-containing preferred translocation partner in lipoma; LPP

LPP

4026

Q93052

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human LPP.

Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes. .

Flow Cytometry

Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures

Immunogen affinity purified.

Liquid

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. .

1. Daheron, L., Veinstein, A., Brizard, F., Drabkin, H., Lacotte, L., Guilhot, F., Larsen, C. J., Brizard, A., Roche, J. Human LPP gene is fused to MLL in a secondary acute leukemia with a t (3;11) (q28; q23) . Genes Chromosomes Cancer 31: 382-389, 2001. 2. Petit, M. M. R., Mols, R., Schoenmakers, E. F. P. M., Mandahl, N., Van de Ven, W. J. M. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36: 118-129, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

65746 MW

No cross reactivity with other proteins.

6

Lipoma-preferred partner

Nucleus. Cytoplasm. Cell junction. Cell membrane. Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.

Belongs to the zyxin/ajuba family.

Lipoma-preferred partner

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.