Antimembraaneiwit 59 TMEM59 Antilichaam

Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.

Boster Bio Anti-Transmembrane protein 59 TMEM59 Antibody (Catalog # A09364) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

C1orf8, HSPC001, C1orf8, UNQ169/PRO195, Transmembrane protein 59, Liver membrane-bound protein

TMEM59

Q9BXS4

Human

TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59. The immunogen is located within amino acids 80 - 130 of TMEM59.

ELISA, WB, IHC-P, IF

Neuroscience

TMEM59 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C) . Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921) . Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278) . Inhibits APP transport to the cell surface and further shedding (PubMed:20427278) .

TMEM59 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A09364

36223 MW

Transmembrane protein 59

Late endosome membrane

Pig, Bovine, Mouse

Transmembrane protein 59

IgG

TMEM59 Antibody is supplied in PBS containing 0.02% sodium azide.