AntiNms Antilichaam fluoro488 Vervoeging

Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. Mice lacking the encoded neuropeptide exhibit decreased heart rate without any accompanying changes in blood pressure. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature peptide.

Transmembrane protein 240; TMEM240; C1orf70

Nms

433292

Q5H8A1

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse Nms recombinant protein (Position: D36-N144) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Miyazato, M., Mori, K., Ida, T., Kojima, M., Murakami, N., Kangawa, K. Identification and functional analysis of a novel ligand for G protein-coupled receptor, neuromedin S. Regul. Pept. 145: 37-41, 2008. 2. Mori, K., Miyazato, M., Ida, T., Murakami, N., Serino, R., Ueta, Y., Kojima, M., Kangawa, K. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 24: 325-335, 2005. 3. Sakamoto, T., Nakahara, K., Maruyama, K., Katayama, T., Mori, K., Miyazato, M., Kangawa, K., Murakami, N. Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice. Peptides 32: 1020-1026, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

19908 MW

6

Transmembrane protein 240

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.