Antiplaatjesfactor 4 PF4 Antilichaam Picoband® fluoro488 Vervoeging

CXCL4, Chemokine (C-X-C motif) ligand 4, is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. CXCL4 belongs to the CXC chemokine family. The CXCL4 gene contains 3 exons spanning approximately 1 kb. The gene is encoded on a 10-kb EcoRI fragment of genomic DNA. By in situ hybridization, the CXCL4 gene is mapped to chromosome 4q12-q21. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.

Platelet factor 4; PF-4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A; Platelet factor 4, short form; PF4; CXCL4, SCYB4

PF4

5196

P02776

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human PF4.

Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Flow Cytometry

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Macrophage/Inflammation, Platelets, Vascular Inflammation

Immunogen affinity purified.

Liquid

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. .

1. Eisman, R., Surrey, S., Ramachandran, B., Schwartz, E., Poncz, M. Structural and functional comparison of the genes for human platelet factor 4 and PF4-alt. Blood 76: 336-344, 1990. 2. Griffin, C. A., Emanuel, B. S., LaRocco, P., Schwartz, E., Poncz, M. Human platelet factor 4 gene is mapped to 4q12-q21. Cytogenet. Cell Genet. 45: 67-69, 1987. 3. Lambert, M. P., Rauova, L., Bailey, M., Sola-Visner, M. C., Kowalska, M. A., Poncz, M. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood 110: 1153-1160, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

10845 MW

No cross reactivity with other proteins.

6

Platelet factor 4

Secreted.

Belongs to the intercrine alpha (chemokine CxC) family.

Platelet factor 4 (PF-4)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.