Antiretinadehydrogenase 1 ALDH1A1 Antibody Picoband® fluoro550 Vervoeging

ALDH1A1 (Aldehyde dehydrogenase 1 family, member A1), also called ALDH1, RALDH1 or ALDH, LIVER CYTOSOLIC, is an enzyme that in humans is encoded by the ALDH1A1 gene. And this protein belongs to the aldehyde dehydrogenases family of proteins. The ALDH1A1 gene is mapped on 9q21.13. ALDH1A1 also belongs to the group of corneal crystallins that help maintain the transparency of the cornea.ALDH1A1 is associated with a low Km for NAD, a high Km for acetaldehyde, and is strongly inactivated by disulfiram. The ALDH1 gene is about 53 kb long and is divided into 13 exons. Retinaldehyde is generated by ADH1 from retinol, and its concentration is determined in large part by its subsequent catabolism by RALDH1 to retinoic acid.

Retinal dehydrogenase 1; RALDH 1; RalDH1;1.2.1.36; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALDH1A1; ALDC, ALDH1, PUMB1

ALDH1A1

216

P00352

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human ALDH1A1, different from the related rat and mouse sequences by one amino acid.

Flow Cytometry

Cancer, Cell Type Marker, Hematopoietic Progenitors, Neurodegenerative Disease, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Stem Cells, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) . .

1. Eckey, R., Agarwal, D. P., Saha, N., Goedde, H. W. Detection and partial characterization of a variant form of cytosolic aldehyde dehydrogenase isozyme. Hum. Genet. 72: 95-97, 1986. 2. Hempel, J., von Bahr-Lindstrom, H., Jornvall, H. Aldehyde dehydrogenase from human liver: primary structure of the cytoplasmic isoenzyme. Europ. J. Biochem. 141: 21-35, 1984. 3. Pereira F, Rosenmann E, Nylen E, Kaufman M, Pinsky L, Wrogemann K (March 1991) . The 56 kDa androgen binding protein is an aldehyde dehydrogenase. Biochem. Biophys. Res. Commun. 175 (3) : 831–8.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

54862 MW

No cross reactivity with other proteins.

6

Retinal dehydrogenase 1

Cytoplasm.

Belongs to the aldehyde dehydrogenase family.

Retinal dehydrogenase 1 (RALDH 1/RalDH1)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.