Antischimmelmiddel 136

Antifungal agent 136 (Compound M-15) is an irreversible fungal lanosterol 14α-demethylase (CYP51) inhibitor. Antifungal agent 136 exhibits potent antifungal activity against drug-resistant Candida albicans and downregulates IL-6 expression. Antifungal agent 136 is promising for research of fungal infection and inflammatory disease[1].

3075607-57-4

12352005

Cytochrome P450; Fungal; Interleukin Related

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Infection; Inflammation/Immunology

10mM

99.60

DMSO : 100 mg/mL (ultrasonic)

C[C@@H](SSCCCC1=CC=NC=C1)[C@@](O)(C2=C(C=C(C=C2)F)F)CN3C=NC=N3

C20H22F2N4OS2

436.54

[1]Sun ZK, et al. Antifungal compounds, preparation methods and uses thereof. CN119431313A. 2025-02-14.

Room Temperature

4°C (Powder, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-W1127089/Antifungal-agent-136-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported

CYP51