Antiserumamyloïde P/APCS Antibody Picoband® fluoro488 Vervoeging

Amyloid P component, serum (SAP), also known as PTX2 or APCS, is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called amyloid. It belongs to the pentraxins family, characterised by calcium dependent ligand binding and distinctive flattened beta-jellyroll structure similar to that of the legume lectins. This gene is mapped to 1q23.2. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Serum amyloid P-component; SAP; Apcs; Ptx2, Sap

APCS

20219

P12246

Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived mouse Serum Amyloid P recombinant protein (Position: Q21-D224) . Mouse Serum Amyloid P shares 70% and 80% amino acid (aa) sequences identity with human and rat Serum Amyloid P, respectively.

Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells.

Flow Cytometry

Adaptive Immunity, Atherosclerosis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Lymphocytic Lineage, Vascular Inflammation

Immunogen affinity purified.

Liquid

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity) . .

1. Cathcart ES, Shirahama T, Cohen AS (1967) . Isolation and identification of a plasma component of amyloid. Biochim. Biophy. Acta 147: 392–393. 2. Entrez Gene: APCS amyloid P component, serum. 3. Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP (1994) . Structure of pentameric human serum amyloid P component. Nature 367 (6461) : 338–45.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26247 MW

No cross reactivity with other proteins.

6

Serum amyloid P-component

Secreted.

Belongs to the pentaxin family.

Serum amyloid P-component

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.