AntisHARPIN Antibody Picoband® FITC Vervoeging

Enables polyubiquitin modification-dependent protein binding activity. Involved in defense response to bacterium; protein linear polyubiquitination; and regulation of signal transduction. Located in cytosol. Part of LUBAC complex.

SHARPIN; SIPL1; PSEC0216; Sharpin; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; hSIPL1

SHARPIN

81858

Q9H0F6

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human SHARPIN recombinant protein (Position: H25-R325) . Human SHARPIN shares 72.3% and 72.6% amino acid (aa) sequence identity with mouse and rat SHARPIN, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Ang, R. L., Chan, M., Legarda, D., Sundberg, J. P., Sun, S. C., Gillespie, V. L., Chun, N., Heeger, P. S., Xiong, H., Lira, S. A., Ting, A. T. Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death. Proc. Nat. Acad. Sci. 118: e2001602118, 2021. 2. Daigo, Y., Takayama, I., Ward, S. M., Sanders, K. M., Fujino, M. A. Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/W (v) mouse. J. Gastroent. Hepatol. 18: 712-718, 2003. 3. Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W.-L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J., Walczak, H. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471: 591-596, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

40 kDa

6

SHANK associated RH domain interactor

Sharpin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.