Antisorbitoldehydrogenase/SORD Antibody Picoband® (monoklonale, 12B10G2)

Sorbitol dehydrogenase is an enzyme that in humans is encoded by the SORD gene. Sorbitol dehydrogenase (SORD) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase, makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications. The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.

Boster Bio Anti-Sorbitol Dehydrogenase/SORD Antibody Picoband® (monoclonal, 12B10G2) catalog # M07851-1. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5; CCT3; CCTG; TRIC5

SORD

6652

Q00796

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Sorbitol Dehydrogenase/SORD recombinant protein (Position: N8-P357) .

Clone: 12B10G2

Ubiquitously expressed with highest levels in spleen, thymus and immature brain.

WB, IHC, Flow Cytometry

Chaperones, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

1. Carr, I. M., Markham, A. F., Coletta, P. L. Identification and characterisation of a sequence related to human sorbitol dehydrogenase. Europ. J. Biochem. 245: 760-767, 1997. 2. Carr, I. M., Markham, A. F. Molecular genetic analysis of the human sorbitol dehydrogenase gene. Mammalian Genome 6: 645-652, 1995. 3. Carr, I. M., Whitehouse, A., Coletta, P. L., Markham, A. F. Structural and evolutionary characterization of the human sorbitol dehydrogenase gene duplication. Mammalian Genome 9: 1042-1048, 1998.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=M07851-1

40 kDa

6

Chaperonin containing TCP1 subunit 3

Cytoplasm.

Mouse IgG1

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.