AntisTAMBP Antibody Picoband® 31.0550 Vervoeging

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

STAMBP; AMSH; STAM-binding protein; EC 3.4.19.-; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase

STAMBP

10617

O95630

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human STAMBP recombinant protein (Position: K187-R424) . Human STAMBP shares 79% and 79.8% amino acid (aa) sequence identity with mouse and rat STAMBP, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Carter, M. T., Geraghty, M. T., De La Cruz, L., Reichard, R. R., Boccuto, L., Schwartz, C. E., Clericuzio, C. L. A new syndrome with multiple capillary malformations, intractable seizures, and brain and limb anomalies. Am. J. Med. Genet. 155A: 301-306, 2011. 2. Ishii, N., Owada, Y., Yamada, M., Miura, S., Murata, K., Asao, H., Kondo, H., Sugamura, K. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Molec. Cell. Biol. 21: 8626-8637, 2001. 3. Isidor, B., Barbarot, S., Beneteau, C., Le Caignec, C., David, A. Multiple capillary skin malformations, epilepsy, microcephaly, mental retardation, hypoplasia of the distal phalanges: report of a new case and further delineation of a new syndrome. (Letter) Am. J. Med. Genet. 155A: 1458-1460, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

48 kDa

6

STAM binding protein

STAM-binding protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.