Antisynip/STXBP4 Antibody Picoband® fluoro647 Vervoeging

Enables syntaxin binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; positive regulation of keratinocyte proliferation; and protein stabilization. Located in extracellular exosome.

Kinesin-like protein KIF20B; Cancer/testis antigen 90; CT90; Kinesin family member 20B; Kinesin-related motor interacting with PIN1; M-phase phosphoprotein 1; MPP1; KIF20B; KRMP1

STXBP4

252983

Q6ZWJ1

Human

No cross-reactivity with other proteins.

E.coli-derived human Synip/STXBP4 recombinant protein (Position: D57-E481) .

Brain, ovary, kidney and testis. Overexpressed in bladder cancer cells. Expressed in testis. Overexpressed in bladder cancer cells.

Flow Cytometry

Cell Biology, Cell Cycle, Cell Division, Cytoskeleton, Cytoskeleton/ECM, Motor Proteins, Signal Transduction, Spindle

Immunogen affinity purified.

Liquid

Plus-end-ed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression.

1. Min, J., Okada, S., Kanzaki, M., Elmendorf, J. S., Coker, K. J., Ceresa, B. P., Syu, L.-J., Noda, Y., Saltiel, A. R., Pessin, J. E. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Molec. Cell 3: 751-760, 1999. Note: Erratum: Molec. Cell 4: following 142, 1999. 2. Saito, T., Okada, S., Yamada, E., Ohshima, K., Shimizu, H., Shimomura, K., Sato, M., Pessin, J. E., Mori, M. Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta-HC-9 cell. J. Biol. Chem. 278: 36718-36725, 2003. 3. Yamada, E., Okada, S., Saito, T., Ohshima, K., Sato, M., Tsuchiya, T., Uehara, Y., Shimizu, H., Mori, M. Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. J. Cell Biol. 168: 921-928, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Kinesin family member 20B

Nucleus. Nucleolus. Nucleoplasm. Centrosome. Spindle. spindle pole. Midbody. Axon. Growth cone.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.