Antitrombosponde 2/THBS2 Antilichaam Picoband® fluoro594 Vervoeging

Thrombospondin-2 (THBS2) is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. The THBS2 is mapped to 6q27 and it is located on chromosome 17. The gene was transcribed in fibroblasts, smooth muscle cells, and an osteosarcoma cell line. It functions as a protein inhibitor of tumor growth and angiogenesis and modulates the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.

Thrombospondin-2; THBS2; TSP2

THBS2

7058

P35442

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human Thrombospondin 2, different from the mouse sequence by two amino acids.

High expression in invertebral disk tissue. .

Flow Cytometry

Angiogenesis, Cancer, Cancer Susceptibility, Epigenetics and Nuclear Signaling, Invasion/Microenvironment, Neural Signal Transduction, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Transcription

Immunogen affinity purified.

Liquid

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. .

1. Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008) . A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. Am J Hum Genet 82 (5) : 1122–9. 2. Hirose, Y., Chiba, K., Karasugi, T., Nakajima, M., Kawaguchi, Y., Mikami, Y., Furuichi, T., Mio, F., Miyake, A., Miyamoto, T., Ozaki, K., Takahashi, A., Mizuta, H., Kubo, T., Kimura, T., Tanaka, T., Toyama, Y., Ikegawa, S.A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.Am. J. Hum. Genet.82: 1122-1129, 2008. 3. Entrez Gene: THBS2 thrombospondin 2.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

129991 MW

No cross reactivity with other proteins.

6

Thrombospondin-2

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.

Belongs to the thrombospondin family.

Thrombospondin-2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.