Antitropomyosine 2/TPM2 Antibody Picoband® fluoro488 Vervoeging

β-Tropomyosin, also known as tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene. This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

TNF receptor-associated factor 5; RING finger protein 84; TRAF5; RNF84

TPM2

7169

P07951

Human, Mouse, Rat

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the N-terminus of human Tropomyosin 2/TPM2, identical to the related mouse and rat sequences.

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, TNF Superfamily

Immunogen affinity purified.

Liquid

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. .

1. Bamshad, M., Watkins, W. S., Zenger, R. K., Bohnsack, J. F., Carey, J. C., Otterud, B., Krakowiak, P. A., Robertson, M., Jorde, L. B. A gene for distal arthrogryposis type I maps to the pericentromeric region of chromosome 9. Am. J. Hum. Genet. 55: 1153-1158, 1994. 2. Clarke, N. F., Domazetovska, A., Waddell, L., Kornberg, A., McLean, C., North, K. N. Cap disease due to mutation of the beta-tropomyosin gene (TPM2) . Neuromusc. Disord. 19: 348-351, 2009. 3. Davidson, A. E., Siddiqui, F. M., Lopez, M. A., Lunt, P., Carlson, H. A., Moore, B. E., Love, S., Born, D. E., Roper, H., Majumdar, A., Jayadev, S., Underhill, H. R., and 14 others. Novel deletion of lysine 7 expands the clinical, histopathological and genetic spectrum of TPM2-related myopathies. Brain 136: 508-521, 2013.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64406 MW

6

TNF receptor-associated factor 5

Cytoplasm . Cytoplasm, cytosol .

Transcription factor E2F3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.