Antizymeremmer 1 (AZIN1) (NM 015878) Humaan Recombinant eiwit

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

Purified recombinant protein of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, Phe260-End, with N-terminal His tag, expressed in E. coli, 50ug

AZI; AZI1; AZIA1; OAZI; OAZIN; ODC1L

51582

O14977, A0A024R9C7

NM_015878

8q22.3

E. coli

N-His

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Druggable Genome

21.2 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

AZIN1

Human

NP_056962

https://www.ncbi.nlm.nih.gov/gene/51582

https://www.uniprot.org/uniprot/O14977

https://www.ncbi.nlm.nih.gov/nuccore/NM_015878

https://www.ncbi.nlm.nih.gov/nuccore/NP_056962