APAF1 Antilichaam

Apoptotic protease activating factor 1. Apaf-1 is a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC) . Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

317

O14727

NP_863658.1

Human, Mouse

307-388

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antigen affinity-purified

1 mg/mL

Phosphate-Buffered Saline. No preservatives added.

None

Blue Ice

APAF1 antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

141.8 kDa (calculated)

Apaf-1 antibody can be used for the detection of Apaf-1 by Western blot, may also work for IHC and ICC.

APAF1

Apoptotic peptidase activating factor 1

Homo sapiens

Cecconi, F., Alvarez-Bolado, G., Meyer, B. I., Roth, K. A. and Gruss, P. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94 (6), 727-737 (1998)

KIAA0413, Apoptotic protease-activating factor 1APAF-1, CED4, APAF-1

WB

32483361

Liquid