APC-Labeled Human HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Tetramer Proteïne

MHC Class I molecules are expressed on nearly all nucleated cells and present peptides to cytotoxic T-cells (CD8+) to survey for infected or cancerous cells. MAGE-A4 is normally silent in adult tissues (except testes and placenta) but is aberrantly expressed in various tumors (e.g., melanoma, lung cancer), making it a prime target for cancer immunotherapy, including T-cell therapies and vaccines.

MHC Class I molecules are expressed on nearly all nucleated cells and present peptides to cytotoxic T-cells (CD8+) to survey for infected or cancerous cells. MAGE-A4 is normally silent in adult tissues (except testes and placenta) but is aberrantly expressed in various tumors (e.g., melanoma, lung cancer), making it a prime target for cancer immunotherapy, including T-cell therapies and vaccines.

APC-Labeled Human HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Tetramer Protein is assembled by biotinylated monomer and APC-labeled streptavidin. Biotinylated Human HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Complex Protein s produced by co-expression of HLA-A*02:01 and B2M loaded with MAGE-A4 peptide. Biotinylated Human HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 36.3 kDa and 11.7 kDa.

Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & GVYDGREHTV peptide

HLA-A*0201 & B2M &MAGE-A4 (GVYDGREHTV)

Biotin-labeled

C-10xHis & C-Avi

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Powder

PBS, 10-15 mg/mL BSA, 50-150 mM NaCl

36.3 kDa and 11.7 kDa

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RT

-20°C, avoid light

25ug*1

HEK293

Human

AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & GVYDGREHTV

Trehalose