APC (NM 001127511) Humaan Recombinant eiwit

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]

Purified recombinant protein of Human adenomatous polyposis coli (APC), transcript variant 1, Glu955-Leu1382, with N-terminal His tag, expressed in E. coli, 50ug

BTPS2; DESMD; DP2; DP2.5; DP3; GS; PPP1R46

324

P25054, Q4LE70

NM_001127511

5q22.2

E. coli

N-His

Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway

Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Druggable Genome

47.7 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

APC

Human

NP_001120983

https://www.ncbi.nlm.nih.gov/gene/324

https://www.uniprot.org/uniprot/P25054

https://www.ncbi.nlm.nih.gov/nuccore/NM_001127511

https://www.ncbi.nlm.nih.gov/nuccore/NP_001120983