APC10 Antilichaam

APC10 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.

10393

Q9UM13

EAX05052

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

APC10 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1401 - Mouse Heart Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

APC10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

APC10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ANAPC10

Anaphase promoting complex subunit 10

Homo sapiens

JM Peters. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol.2006; 7:644-56.

Jorgensen PM, Graslund S, Betz R, et al. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Gene2001; 262:51-9.

Passmore LA, McCormack EA, Au SWN, et al. Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J.2003; 22:786-96.

APC10 Antibody: DOC1, APC10, Anaphase-promoting complex subunit 10, Cyclosome subunit 10

ELISA, WB, IHC-P, IF

119625457

Liquid