APC6 Antilichaam

APC6 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.

8881

Q13042

NP_003894

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

APC6 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 - Human Liver Tissue Lysate

1 mg/mL

APC6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

APC6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CDC16

Cat. No. 10-201 - Human Liver Tissue Slide

Cell division cycle 16 homolog (S. cerevisiae)

Homo sapiens

JM Peters. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol.2006; 7:644-56.

Jorgensen PM, Graslund S, Betz R, et al. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Gene2001; 262:51-9.

Wang J, Dye BT, Rajashankar KR, et al. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC structure. Nat. Struct. Mol. Biol.2009; 16:987-9.

APC6 Antibody: APC6, CUT9, ANAPC6, Cell division cycle protein 16 homolog, Anaphase-promoting complex subunit 6, APC6

ELISA, WB, IHC-P, IF

118402580

Liquid