APEX1 Antilichaam

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

328

P27695

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1 (NP_542380.1) .

Unconjugated

Primary Antibodies

Transcription

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 39kDa

IgG

APEX1

HepG2

APEX nuclease (multifunctional DNA repair enzyme) 1

Homo sapiens

APEX1, APE, APX, APE1, APEN, APEX, HAP1, REF1

WB, IHC, IF

Liquid