APL180 (TFA)

APL180 TFA (L-4F) is an apolipoprotein AI mimetic peptide that enhances the anti-inflammatory activity of high-density lipoprotein (HDL) . APL180 can be used in the study of cardiovascular diseases.

L-4F (TFA)

12352209

Apolipoprotein

Metabolic Enzyme/Protease

Neuroscience-Neuromodulation

Cardiovascular Disease

98.80

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CC4=CC=CC=C4)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC([C@@H](NC(C)=O)CC(O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

C114H156N24O28.xC2HF3O2

2310.60 (free base)

[1]Watson CE, et al. Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function. J Lipid Res. 2011 Feb;52 (2) :361-73.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P6365/APL180-TFA-SDS-MedChemExpress.pdf

Peptides

Phase 2