APO-15

APO-15 is a fluorogenic imaging agent targeting phosphatidylserine (PS) exposed on the cell membrane of apoptotic cells. APO-15 can selectively bind to apoptotic cells, enabling staining and imaging of apoptotic cells in a calcium-independent and wash-free manner. APO-15 is promising for research of inflammatory diseases and cancers[1].

3051946-11-0

12352209

Ser/Thr Kinase

Metabolic Enzyme/Protease

Cancer; Inflammation/Immunology

99.45

DMSO : 50 mg/mL (ultrasonic)

CC1=C2N(C(C)=C1)[B-](F)(F)[N+]3=C(C)C=C(C)C3=C2C4=CC=CC(C(NC5=CC=CC=C65)=C6C[C@@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CC7=CNC8=C7C=CC=C8)C9=O)=O)CCCCN)=O)CCCCN)=O)=O)=O)NC([C@H](CC%10=CC=CC=C%10)N9)=O)=C4

C70H85BF2N16O7

1311.33

[1]Barth ND, et al. A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis. Nat Commun. 2020 Aug 12;11 (1) :4027.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10943/APO-15-SDS-MedChemExpress.pdf

Peptides

No Development Reported