APO-E Antilichaam

APO-E Antibody: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

348

P02649

NP_000032

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

APO-E Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (78%)

APO-E Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

APO-E antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

APOE

Cat. No. 10-201 - Human Liver Tissue Slide

Apolipoprotein E

Homo sapiens

Vasquez EC, Peotta VA, Gava TMC, et al. Cardiac and vascular phenotypes in the epolipoprotein E-deficient mouse. J. Biomed. Sci. 2012; 19:22.

Feussner G, Funke H, Weng W, et al. Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype. Eur. J. Clin. Invest. 1992; 22:599-608.

APO-E Antibody: AD2, LPG, LDLCQ5, Apolipoprotein E, Apo-E

ELISA, WB, IHC-P, IF

4557325

Liquid