APOB-antilichaam

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

338

P04114

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 28-330 of human APOB (NP_000375.2) .

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Affinity purification

LO2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

APOB

HepG2

HL-60

Mouse liver

Mouse kidney

Rat liver

Apolipoprotein B

Homo sapiens

APOB, apolipoprotein B (including Ag (x) antigen), FLDB, apoB-100, apoB-48, apolipoprotein B, apolipoprotein B48, LDLCQ4

WB, IF

Liquid