APRIL Antilichaam

APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1α (for TNF related death ligand 1α ) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κ B, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

8741

O75888

NP_003799

Human

Unconjugated

Primary Antibodies

Chemokines & Cytokines, Cancer

APRIL Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/ml

APRIL Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

APRIL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

27 kDa

IgG

TNFSF13

Tumor necrosis factor (ligand) superfamily, member 13

Homo sapiens

Hahne M, Kataoka T, Schroter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med. 1998;188 (6) :1185-90.

Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol. 1999;65 (5) :680-3.

Kelly K, Manos E, Jensen G, et al. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000;60 (4) :1021-7.

Yu G, Boone T, Delaney J, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000;1 (3) :252-6.

APRIL Antibody: APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715, APRIL, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand

ELISA, WB

4507599

Liquid