Aprindine (hydrochloride) (standaard)

Aprindine hydrochloride (Standard) is the analytical reference standard of Aprindine hydrochloride. This product is used for research and analytical applications. Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias.

33237-74-0

12352100

Calcium Channel; Calmodulin; Potassium Channel; Reference Standards; Sodium Channel

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Cardiovascular Disease

CCN(CC)CCCN(C1CC2=C(C=CC=C2)C1)C3=CC=CC=C3.[H]Cl

C22H31ClN2

358.95

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-A0236AR/

Reference Standards