APRT Antilichaam - N-terminalgebied: FITC (ARP58422 P050-FITC)

Adenine phosphoribosyltransferase

AMP, APRTD

353

P07741

NP_000476

Human, Rat, Cow, Dog, Guinea Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human APRT

Adenine phosphoribosyltransferase (APRT) belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP) . It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP) . It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.

UBC; FN1; VCAM1; MLH1; ITGA4; NAPRT; HECW2; GMPS; UMPS; HPRT1; APP; IKBKG; APRT; VHL

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB, IHC

Affinity Purified

APRT is strongly supported by BioGPS gene expression data to be expressed in HEK293T

0.5 mg/ml

Cow: 79%; Dog: 79%; Guinea Pig: 86%; Human: 100%; Rat: 77%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

20kDa

Silva, C.H., (2008) J. Biomol. Struct. Dyn. 25 (6), 589-597

Wet Ice

180

APRT

APRT

Rabbit

Adenine phosphoribosyltransferase

NM_000485

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