APY-d3
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
APY-d3 is a EphA4-LBD antagonistic peptide with a Kd of 138 nM. APY-d3 is constrained into a bioactive β-hairpin conformation via a head-to-tail disulfide bond. APY-d3 can be used for cancers like gastric and pancreatic cancers and neurodegenerative diseases like amyotrophic lateral sclerosis and Alzheimer’s disease research[1].
12352209
Ephrin Receptor
Protein Tyrosine Kinase/RTK
Cancer; Neurological Disease
O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CSSC[C@@H](C(O)=O)NC2=O)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CCCNC(NC(CCN)=O)=N)C(N[C@@H](CO)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@H]2CO)=O)=O)=O)=O)=O)=O)=O)[C@H]6N(C(CCN)=O)CCC6
C63H86N16O17S2
1403.58
[1]Prentiss AM, et al. Constrained β-Hairpins Targeting the EphA4 Ligand Binding Domain. J Med Chem. 2024 Dec 26;67 (24) :22245-22253.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P11035/
Peptides
No Development Reported
EphA
Beschrijving
APY-d3 is a EphA4-LBD antagonistic peptide with a Kd of 138 nM. APY-d3 is constrained into a bioactive β-hairpin conformation via a head-to-tail disulfide bond.
Specificaties
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