AQP2 Antilichaam

Aquaporins are membrane proteins that serve in the transfer of water and small solutes across cellular membranes. One such aquaporin, aquaporin-2 (AQP2) is located in the kidney collecting tubule and plays a critical role in water reabsorbtion (1) . AQP2 is mainly localized in intracellular vesicles but upon stimulation with anti-diuretic hormone (ADH), AQP2 is translocated to the apical plasma membrane by exocytic fusion of AQP2-bearing vesicles (2) . Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus (3) .

359

P41181

NP_000477

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

AQP2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Sheep: (100%), Bovine: (95%)

AQP2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

AQP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

AQP2 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with other members of the aquaporin protein family.

AQP2

Cat. No. 10-401 - Human Kidney Tissue Slide

Aquaporin 2 (collecting duct)

Homo sapiens

Denker BM, Smith BL, Kuhada FP, et al. Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J. Biol. Chem. 1988; 263:15634-42.

Barile M, Pisitkun T, Yu MJ, et al. Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Mol. Cell Proteomics 2005; 4:1095-106.

Bockenhauer D and Bichet DG. Inherited secondary nephrogenic diabetes insipidus: concentrating on humans. Am. J. Physiol. Renal Physiol. 2013; 304:F1037-42.

AQP2 Antibody: AQP-CD, WCH-CD, Aquaporin-2, ADH water channel, AQP-2

ELISA, WB, IHC-P, IF

4502179

Liquid