Ardeemin
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Ardeemin ((-) -Ardeemin) binds to the P-glycoprotein, preventing anticancer agent from being pumped out of cells. Ardeemin reverses the multidrug resistance phenotype of tumor cells and increases the sensitivity of tumor cells to anticancer agent in mammary carcinoma xenografts[1].
148441-25-2
(-) -Ardeemin
12352005
P-glycoprotein
Membrane Transporter/Ion Channel
Cancer
C=CC(C)([C@]12[C@](NC3=CC=CC=C32)([H])N4[C@@](C(N5[C@@H](C4=O)C)=NC6=CC=CC=C6C5=O)([H])C1)C
C26H26N4O2
426.51
[1]Haynes SW, et al., Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. ACS Chem Biol. 2013 Apr 19;8 (4) :741-8.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-N5166/
Natural Products
No Development Reported
Beschrijving
Ardeemin ((-) -Ardeemin) binds to the P-glycoprotein, preventing anticancer agent from being pumped out of cells. Ardeemin reverses the multidrug resistance phe
Specificaties
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