Arecoline HBr
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM) . ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM) .2 May be effective in dementia.3
Unconjugated
White solid
RT
Beschrijving
Arecoline HBr Beschikbaar in 250 mg. Bestel eenvoudig online met snelle levering.
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