ARF6 Antilichaam

The ADP-ribosylation factor 6 (ARF6) is a member of the ARF family, which is part of the RAS superfamily (1) . The ARF proteins are small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D (2) . The product of this gene is localized to the plasma membrane (3), and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling (4) .

382

P62330

NP_001654

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

ARF6 antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (100%)

ARF6 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ARF6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ARF6 antibody is human, mouse and rat reactive.

ARF6

Cat. No. 10-401 - Human Kidney Tissue Slide

ADP-ribosylation factor 6

Homo sapiens

Graves RA, Tontonoz P, and Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell Biol. 1992; 12:1202-8.

Moss J and Vaughan M. Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors. Mol Cell Biochem. 1999; 193:153-7.

Cavenagh MM, Whitney JA, Carroll K, et al. Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane. J. Biol. Chem. 1996; 271:21767-74.

Schweitzer JK, Sedgewick AE, and D'Souza-Schorey C. ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homestasis. Semin. Cell Dev. Biol. 2011; 22:39-47.

ARF6 Antibody: ADP-ribosylation factor 6

ELISA, WB, IHC-P, IF

4502211

Liquid