ARFL1 Polyklonale Antilichaam, Cy3 Vervoeging

The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins (13) . ARFs influence vesicle trafficking and signal transduction in eukaryotic cells (13) . ARF-dependent regulatory mechanisms include the coordination of spectrin interactions with golgi membranes and the association of actin to the golgi via rho family-dependent G-protein localization (Rac, CDC42) and WASP/Arp2/3 complexes (37) . Additionally, ARFs play a central role in maintenance of organelle integrity, assembly of coat proteins, and activation of phospholipase D (57) . The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6) ; members of each class share a common gene organization (8,9) . The human ARF6 gene maps to chromosome 7q22.1, contains five exons and four introns, and encodes a 175 amino acid protein (8,9) .

ADP ribosylation factor like 1; ADP-ribosylation factor-like protein 1; ARFL1; Arl1; ARL1_HUMAN.

400

Cytoplasm, Cell membrane

101-181/181

ARFL1

Cy3

KLH conjugated synthetic peptide derived from human ARFL1

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

512,550nm/570,615nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

400

Human, Mouse, Rat, Sheep, Pig, Chicken, Rabbit