Argyrin A

Argyrin A, a cyclical peptide, is a potent antitumoral agent. Argyrin A exerts its effects through a potent inhibition of the proteasome. Argyrin A leads to increased endogenous p27kip1 levels by preventing protein turnover[1].

174423-37-1

12352005

Proteasome

Metabolic Enzyme/Protease

Cancer

COC1=C2C(C[C@@H]3NC([C@@H](NC(C4=CSC([C@H](NC(CN(C(C(NC([C@H](NC(CNC3=O)=O)C)=O)=C)=O)C)=O)C)=N4)=O)CC5=CNC6=CC=CC=C56)=O)=CNC2=CC=C1

C40H44N10O8S

824.90

[1]Nickeleit I, et al. Argyrin a reveals a critical role for the tumor suppressor protein p27 (kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell. 2008 Jul 8;14 (1) :23-35.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N13904/

Natural Products

No Development Reported