Argyrin F

Argyrin F a cyclic peptide with antitumoral activities. Argyrin F inhibits cell proliferation, migration, invasion and colony formation by partial induction of apoptosis and epithelial-mesenchymal transition (EMT) . Argyrin F stabilizes p27kip, up-regulated p21waf1/cip1 and depletes COX2. Argyrin F can be used for the study of pancreatic ductal adenocarcinoma (PDAC) [1].

444300-74-7

12352005

Apoptosis

Apoptosis

Cancer

COC1=C2C(C[C@@H]3NC([C@@H](NC(C4=CSC([C@H](NC(CN(C(C(NC([C@H](NC(CNC3=O)=O)C)=O)=C)=O)C)=O)CO)=N4)=O)CC5=CNC6=CC=CC=C56)=O)=CNC2=CC=C1

C40H44N10O9S

840.90

[1]Chen X, et al. Therapeutic effects of Argyrin F in pancreatic adenocarcinoma. Cancer Lett. 2017 Jul 28;399:20-28.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N13944/

Natural Products

No Development Reported