ARID1A Antilichaam

The ARID1A protein is a member of the SWI/SNF family, whose members are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. ARID1A is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin (1) . It possesses a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. The C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that ARID1A confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions (2) .

8289

O14497

NP_006006

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Signal Transduction

ARID1A antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

ARID1A antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ARID1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ARID1A antibody is human, mouse and rat reactive. Multiple isoforms of ARID1A protein are known to exist.

ARID1A

AT rich interactive domain 1A (SWI-like)

Homo sapiens

Martens JA and Winston F. Recent advances in understanding chromatin remodeling by Swi/Snf complexes. Curr. Opin. Genet. Dev. 2003; 13:136-42.

Nie Z, Xue Y, Yang D, et al. A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol. Cell. Biol. 2000; 20:8879-88.

AT rich interactive domain 1A (SWI-like), RP1-50O24.1, B120, BAF250, BAF250a, BM029, C1orf4, ELD, hELD, MRD14, OSA1, hOSA1, P270, SMARCF1

ELISA, WB, IHC-P, IF

21264565

Liquid