ARMER Antilichaam

ARMER Antibody: Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

23204

Q15041

Q15041

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

ARMER Antibody is Ion exchange chromatography purified.

Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

1 mg/mL

ARMER Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ARMER antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ARL6IP1

ADP-ribosylation factor-like 6 interacting protein 1

Homo sapiens

Stellar H. Mechanisms and genes of cellular suicide. Science 1995; 267:1445-9.

Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β . Nature 2000; 403:98-103.

Lui HM, Chen J, Wang L, et al. ARMER, Apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis. Mol. Cancer Res. 2003; 1:508-18.

ARMER Antibody: AIP1, ARMER, SPG61, ARL6IP, KIAA0069, ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1

ELISA, WB, IHC-P, IF

14424435

Liquid