Aromatase (CYP19A1) (NM 000103) Humaan Recombinant Proteïne

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

Purified recombinant protein of Human cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 1, Tyr241-end, with N-terminal His tag, expressed in E. coli, 50ug

ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM

1588

P11511, A0A024R5S8, Q8TCA4, Q8IYG4

NM_000103

15q21.2

E. coli

N-His

Androgen and estrogen metabolism, Metabolic pathways

Androgen and estrogen metabolism, Metabolic pathways

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0

Druggable Genome, P450

30.7 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

CYP19A1

Human

NP_000094

https://www.ncbi.nlm.nih.gov/gene/1588

https://www.uniprot.org/uniprot/P11511

https://www.ncbi.nlm.nih.gov/nuccore/NM_000103

https://www.ncbi.nlm.nih.gov/nuccore/NP_000094